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Lamotrigine and the Risk of Malformations in Pregnancy Neurol 64:955-960, 938, Cunnington, M. , et al, 2005 See this aricle in Pubmed Article Abstract The risk of all major birth defects after first-trimester exposure to lamotrigine monotherapy (2.9%) was similar to that in the general population and in other registries enrolling women exposed to antiepileptic monotherapy (3.3% to 4.5%). However, the sample size was too small to detect any but very large increases in specific birth defects.

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